Rodriguez revealed that she had spent four days in hospital with pneumonia and informed her fans on social media that she is on the mend as she continues to recover at home.
Ronaldo, who turned out for his club side in their two previous fixtures over the last week, missed the stalemate against bottom-half side Al Kholood.
The Sun reported that Rodriguez was admitted to Saudi German Hospital in Riyadh, Saudi Arabia, where she is based with Ronaldo.
The influencer and model has been with the Portuguese superstar since 2016 after they met at a Gucci retail store in Madrid.
Cristiano Ronaldo missed Al-Nassr's Saudi Pro League clash on Friday night following the news that his partner had been in hospital with pneumonia
They have two children together, while Ronaldo has three other children from previous relationships.
Rodriguez said in a post on social media: 'Finally back home! I spent four days in the hospital with pneumonia, I'm better now but still recovering at home with my family.
'I have to say a big THANK YOU to all the staff members, doctors, nurses and everyone at the hospital... they took care of me so wonderfully and I am very grateful for that.
When Ronaldo joined Al-Nassr in January 2023, it was reported that alongside Rodriguez, they were given permission by the rulers of the kingdom to live together.
This was an exception to the rule that unmarried couples are not allowed to live together in Saudi Arabia.
Meanwhile, speaking in the latest season of her hit Netflix reality show, 'I Am Georgina', Rodriguez revealed how elated she was once she learned Ronaldo was moving to the Middle East at the end of 2022.
'When Cris told me he was going to play for Al-Nassr, I was so relieved because I really wanted to leave Manchester,' Rodriguez said.
Rodriguez added: 'I knew something big was waiting for us and we were highly motivated. I was very happy to come to Saudi Arabia'.
However, the couple and their kids' transition to life in Saudi Arabia was not smooth sailing.
'It all happened so quickly,' Rodriguez said. 'At the beginning, I had some ups and downs because we had never lived in a hotel for so long. There were days when I didn't want anyone to see me, but overall, I was very excited.'