The Spanish midfielder went down clutching his knee after jostling for position with Arsenal's Thomas Partey inside the box.
Unfortunately for City, Rodri required further medical attention and had to be helped off the field.
The 28-year-old was visibly emotional as he received treatment on the field as well.
Rodri fell to the ground and clutched his right knee after a challenge with Thomas Partey
Earlier in the match, Rodri fell to the ground only a few seconds after City had kicked off as Gunners forward Kai Havertz ran into him.