The Genetics of Handedness: Unlocking the Left-Brain Enigma

The Genetics of Handedness: Unlocking the Left-Brain Enigma
The Genetics of Handedness: Unlocking the Left-Brain Enigma

Genetic Link to Left-Handedness

Left-handedness, a trait prevalent in approximately 10% of the population, has long puzzled scientists. A recent study sheds light on a genetic component contributing to this unique characteristic.

Researchers have identified rare variants of a gene called TUBB4B, involved in controlling the shape of cells, which are 2.7 times more common in left-handed individuals. Although these variants account for a small fraction of left-handedness, they suggest a role for TUBB4B in establishing the brain asymmetry underlying hand dominance.

Brain Asymmetry and Hand Dominance

The two hemispheres of the brain differ slightly in anatomy and specialization. In most people, the left hemisphere dominates language processing, while the right hemisphere is responsible for tasks requiring spatial attention. The left hemisphere also controls the dominant right hand through nerve fibers crossing from left to right in the brain. In left-handers, this pattern is reversed, with the right hemisphere controlling the dominant hand.

TUBB4B and Microtubules

TUBB4B regulates the incorporation of proteins into microtubules, structural components of cells. The discovery of rare mutations in this gene more prevalent in left-handers suggests that microtubules play a role in establishing brain asymmetries.

Possible Mechanisms

The development of different hemispheres in the embryo remains unclear, but rare genetic variants in TUBB4B provide clues to the underlying mechanisms. These variants may disrupt the normal formation of microtubule-based structures, affecting brain asymmetry and hand dominance.

Cultural Influences

Historically, left-handedness has been stigmatized in many cultures, leading to attempts to force lefties to become right-handed. This suppression has likely contributed to the varying prevalence of left-handedness worldwide.

Psychiatric Implications

Intriguingly, left-handedness and ambidexterity are more common in individuals with schizophrenia and autism. This suggests that genes involved in brain development during infancy may influence both brain asymmetry and psychiatric traits.


The study provides evidence of a genetic component to left-handedness, involving the TUBB4B gene. The findings contribute to our understanding of the complex mechanisms underlying brain asymmetry and hand dominance, with potential implications for psychiatry.

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