Captain Kane has been cleared to remain with the national team at St George’s Park after suffering ankle and groin issues in the weekend game against Eintracht Frankfurt.
The news will come as a key boost to Carsley, who is aiming to maintain his 100 percent record since replacing Gareth Southgate at the helm as he tries to land the boss’ job on a permanent basis.
Lee Carsley has suffered a triple blow, with Ezri Konsa and Morgan Gibbs-White also out
The central midfielder appeared to suffer a hamstring problem in the defeat to Tottenham on September 29 but did complete 85 minutes of Sunday’s goalless draw at Aston Villa.
It is understood Mainoo's withdrawal is precautionary.
Konsa also suffered a hamstring injury in the game at Villa Park, while Gibbs-White was forced off in their 1-1 draw at Chelsea with a suspected knee issue.