Italy's coach Gonzalo Quesada has announced three significant changes to the starting lineup for their upcoming Six Nations match against England in Rome.

Fullback Ange Capuozzo is sidelined due to injury, with Lorenzo Pani returning to the fullback position. Centre Juan Ignacio Brex is back in the team, resuming his midfield partnership.

Scrumhalf Alessandro Garbisi has been promoted to the starting team and will play alongside his flyhalf brother, Paolo Garbisi. This promotion sees Alessandro Fusco move to the replacements. Tommaso Allan also returns to the squad as a replacement flyhalf.

Italy is seeking its first-ever victory over England, having lost all 32 previous encounters. The team's recent performances and England's recent results have generated optimism for this fixture.