The 2026 NFL schedule is out, and sportsbooks have already posted opening lines for Week 1. The slate kicks off Wednesday, Sept. 9, with a Super Bowl rematch: the New England Patriots face the Seattle Seahawks, with Seattle favored by 3.5 points.
Thursday night marks history as the Rams host the 49ers in the NFL's first regular-season game in Australia. Los Angeles opens as a 2.5-point favorite.
Sunday's biggest spread belongs to the Chargers, who are 11.5-point favorites over the Cardinals. The Jaguars are 7-point favorites over the Browns, and the Lions are also 7-point favorites against the Saints.
The Cowboys visit the Giants as 2.5-point road favorites, while the defending champion Eagles host the Commanders as 5.5-point chalk.
Week 1 closes Monday, Sept. 14, with the Broncos at the Chiefs. Kansas City is a 2.5-point favorite.