Long-acting injectable antiretroviral therapy (ART) shows promise in Pakistan, potentially easing pill burden, improving adherence, and enhancing privacy for individuals living with HIV.
Interviews and a focus group discussion with patients and peer advocates in Pakistan revealed significant appeal for injectable ART. Participants favored its ability to eliminate daily pill regimens, thereby supporting consistent adherence. Furthermore, the injectable format was associated with fewer logistical demands and greater personal privacy, offering a less conspicuous treatment option.
Despite these advantages, several barriers to widespread adoption were identified. Concerns about injection-related adverse events were prominent. Practical system challenges, including extended clinic waiting times and limited availability of the treatment, were also cited as potential hindrances to ongoing dosing. Some individuals also expressed contentment with their established oral ART regimens and the convenience of multi-month prescription refills, while others noted work schedules that could complicate clinic-based injections.
Overall, long-acting injectable ART was deemed acceptable by many, primarily for its adherence and privacy benefits. The study authors suggest that successful implementation hinges on effectively addressing safety concerns, ensuring reliable supply and access, and fostering responsive, stigma-free, people-centered care models.