Migraine often worsens during the menopause transition due to fluctuating estrogen levels, leading to more frequent and severe attacks.

Some women develop migraine aura for the first time, requiring careful evaluation. Stroke risks also rise with migraine with aura in midlife women. While preventive treatments like CGRP therapies exist, hormone therapy presents mixed benefits. Stabilizing estrogen through transdermal estradiol may help, but vigilance is key.
Post-menopause, around half of women continue to experience migraine, underscoring the need for tailored care.