A new preclinical study suggests branched-chain amino acids (BCAAs) may reduce gut inflammation and improve constipation in Parkinson's disease.
Parkinson's is increasingly recognized as a systemic condition. Gastrointestinal issues like constipation are among the earliest non-motor symptoms, often appearing years before neurological decline.
The study used a mouse model of Parkinson's and found that BCAAs improved constipation and reduced inflammatory T-cell activity in the gut.
Microbial analysis showed lower circulating BCAA levels in affected mice. Supplementation helped restore immune balance.
The findings provide insight into the gut-brain connection in Parkinson's. Further clinical research is needed to confirm the potential role of BCAAs in managing gastrointestinal symptoms.