A new study from the University of Rochester indicates that a simple combination of over-the-counter ibuprofen and a home exercise program may help alleviate cognitive impairments known as "chemo brain" in cancer patients undergoing chemotherapy.
Chemo brain, or chemotherapy-related cognitive impairment (CRCI), affects up to 80% of chemotherapy patients, impacting memory, concentration, and multitasking. The phase 2 trial involved 86 adult cancer patients in New York, with an average age of 53; nearly 89% were women.
Participants were assigned to four groups: home exercise, exercise plus ibuprofen, ibuprofen alone, or placebo. After six weeks, the exercise group showed the clearest improvements in attention and cognitive function. Those taking only ibuprofen also performed better than the placebo group, though the effect was less pronounced.
"We are encouraged by the findings of this trial that suggest possible benefits of both interventions for some cognitive domains," said lead author Michelle C. Janelsins of the University of Rochester and the Wilmot Cancer Institute.
Researchers believe inflammation may play a role in CRCI, suggesting anti-inflammatory medications could be effective. No adverse side effects were reported. Larger phase 3 trials are planned, and experts advise patients to consult their oncology team before starting new treatments.