AN ELECTRONIC health record integrated AI agent demonstrates improved diagnostic accuracy and clinical decision making, outperforming physicians in real patient simulations. The system, MIRA (Medical Intelligence for Reasoning and Action), operates autonomously within a controlled EHR environment, executing clinical actions safely. It retrieves patient histories, interprets tests, and generates diagnoses and treatment plans.

In evaluations, MIRA showed higher diagnostic accuracy than human physicians, producing guideline-concordant recommendations and safe medication decisions. Its broad action capabilities allow it to effectively translate clinical intent into structured EHR actions, which is a significant advancement over previous AI applications focused on narrow tasks.

This development suggests that AI systems integrated into EHRs could significantly support clinical reasoning and decision-making across healthcare systems. Such systems may best serve in collaborative environments, assisting physicians by handling routine tasks and offering evidence-based recommendations, which remain under physician oversight. However, further research is needed to assess effectiveness and safety in real-world clinical settings.