Fibre May Accelerate Gut Recovery in Coeliac Patients

Patients with coeliac disease experience disrupted microbial fibre metabolism in the small intestine, even while adhering to a strict gluten-free diet (GFD).

A new study reveals that coeliac disease leads to a significant depletion of Prevotella species-bacteria vital for breaking down dietary fibre. This loss reduces short-chain fatty acid (SCFA) production, which supports intestinal repair and reduces inflammation.

In preclinical models, reintroducing Prevotella and feeding an inulin-rich diet boosted SCFA levels and accelerated mucosal healing in gluten-sensitised mice with the HLA-DQ8 gene.

These findings suggest that fibre supplementation may enhance gut recovery beyond traditional dietary restrictions. However, clinical trials are needed to confirm real-world benefits.